International journal of radiation oncology, biology, physics
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Int. J. Radiat. Oncol. Biol. Phys. · Oct 2005
Rectal wall sparing effect of three different endorectal balloons in 3D conformal and IMRT prostate radiotherapy.
To investigate the dosimetric consequences and rectal wall (Rwall) sparing effect of three different endorectal balloons (ERBs) for three-dimensional conformal radiotherapy (3D-CRT) and intensity-modulated radiotherapy (IMRT) for prostate cancer. ⋯ In 3D-CRT, any ERB showed a significant rectal wall sparing effect. ERB2 and ERB3 were superior to ERB1. For both 3D-CRT and IMRT, a reduction of the relative inner Rwall surface exposed to intermediate and high doses was found, which may lead to reduced late rectal toxicity. Development of user- and patient-friendly ERBs is warranted to increase their acceptability.
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Int. J. Radiat. Oncol. Biol. Phys. · Oct 2005
High-dose radiation improved local tumor control and overall survival in patients with inoperable/unresectable non-small-cell lung cancer: long-term results of a radiation dose escalation study.
To determine whether high-dose radiation leads to improved outcomes in patients with non-small-cell lung cancer (NSCLC). ⋯ Higher dose radiation is associated with improved outcomes in patients with NSCLC treated in the range of 63-103 Gy.
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Int. J. Radiat. Oncol. Biol. Phys. · Oct 2005
Prostate-specific antigen doubling time predicts clinical outcome and survival in prostate cancer patients treated with combined radiation and hormone therapy.
To determine whether prostate-specific antigen (PSA) doubling time predicts clinical outcomes in patients with prostate cancer that has been treated with combined radiation and hormone therapy. ⋯ In men with prostate cancer that has been treated with combined hormone and radiation therapy, a posttreatment PSADT of < or =8 months is associated with worse clinical outcomes and may be an early surrogate marker for decreased survival. These patients should be considered for more aggressive salvage therapy protocols.
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Int. J. Radiat. Oncol. Biol. Phys. · Oct 2005
Reirradiation of recurrent high-grade gliomas using amino acid PET (SPECT)/CT/MRI image fusion to determine gross tumor volume for stereotactic fractionated radiotherapy.
To develop a valid treatment strategy for recurrent high-grade gliomas using stereotactic hypofractionated reirradiation based on biologic imaging and temozolomide. ⋯ This is the first study of biologic imaging optimized SFRT plus temozolomide in recurrent high-grade gliomas. It demonstrates the feasibility and safety of this approach. The most striking result of the trial is the statistically significant longer survival time in the univariate analysis for patients reirradiated using MET-PET or IMT-SPECT/CT/MRI image fusion in the treatment planning, in comparison to patients treated based on MRI/CT alone. Multivariate analysis confirmed a significant survival benefit from multimodal treatment (i.e., addition of temozolomide), despite the limited number of patients. Whether treatment planning with SPECT/PET independently influences survival has to be studied in a larger series of patients.
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Int. J. Radiat. Oncol. Biol. Phys. · Oct 2005
Comparative StudyTreatment planning with protons for pediatric retinoblastoma, medulloblastoma, and pelvic sarcoma: how do protons compare with other conformal techniques?
To calculate treatment plans and compare the dose distributions and dose-volume histograms (DVHs) for photon three-dimensional conformal radiation therapy (3D-CRT), electron therapy, intensity-modulated radiation therapy (IMRT), and standard (nonintensity modulated) proton therapy in three pediatric disease sites. ⋯ In the diseases studied, using various techniques of 3D-CRT, electrons, IMRT, and protons, protons are most optimal in treating retinoblastomas, medulloblastomas (posterior fossa and craniospinal), and pelvic sarcomas. Protons delivered superior target dose coverage and sparing of normal structures. As dose-volume parameters are expected to correlate with acute and late toxicity, proton therapy should receive serious consideration as the preferred technique for the treatment of pediatric tumors.