International journal of radiation oncology, biology, physics
-
Int. J. Radiat. Oncol. Biol. Phys. · Feb 2007
Multicenter StudyReduced-intensity conditioning regimen using low-dose total body irradiation before allogeneic transplant for hematologic malignancies: Experience from the European Group for Blood and Marrow Transplantation.
The high rate of toxicity is the limitation of myeloblastive regimens before allogeneic transplantation. A reduced intensity regimen can allow engraftment of stem cells and subsequent transfer of immune cells for the induction of a graft-vs.-tumor reaction. ⋯ In this multicenter study, we confirmed high rates of engraftment and chimerism after the reduced intensity regimen. Our results are comparable to those previously reported. Radiation parameters seem to have no impact on outcome. However, the lack of a statistically significant difference in terms of dose rate may have been due, in part, to the small population size in the subgroup analysis.
-
Int. J. Radiat. Oncol. Biol. Phys. · Feb 2007
Combined-modality treatment for advanced oral tongue squamous cell carcinoma.
The aim of this study was to investigate prognostic factors in advanced-stage oral tongue cancer treated with postoperative adjuvant therapy and to identify indications for adjuvant concomitant chemoradiotherapy (CCRT). ⋯ Based on this study, ECS appears to be an absolute indication for adjuvant CCRT. CCRT can not be shown to be statistically better than radiotherapy alone in this retrospective series when ECS is not present.
-
Int. J. Radiat. Oncol. Biol. Phys. · Feb 2007
Effect of anatomic motion on proton therapy dose distributions in prostate cancer treatment.
To determine the dosimetric impact of interfraction anatomic movements in prostate cancer patients receiving proton therapy. ⋯ A comparison of passively scattered proton therapy and highly conformal IMRT plans for prostate cancer revealed that the dosimetric impact of interfractional anatomic motions was similar for both modalities.
-
Int. J. Radiat. Oncol. Biol. Phys. · Feb 2007
Functional outcome and survival after radiotherapy of metastatic spinal cord compression in patients with cancer of unknown primary.
Patients with cancer of unknown primary (CUP) account for about 10% of patients with metastatic spinal cord compression (MSCC). This study aims to define the appropriate radiation regimen for these patients. ⋯ For MSCC treatment in patients with CUP, no significant difference was observed between short-course and long-course RT regarding functional outcome and survival. Short-course RT appears preferable, at least for patients with a poor predicted survival, as it is more patient convenient and more cost-effective.
-
Int. J. Radiat. Oncol. Biol. Phys. · Feb 2007
Comparison of high-dose-rate and low-dose-rate brachytherapy in the treatment of endometrial carcinoma.
To compare the outcomes for endometrial carcinoma patients treated with either high-dose-rate (HDR) or low-dose-rate (LDR) brachytherapy. ⋯ Survival outcomes, pelvic tumor control, and Grade III and IV complications were not significantly different in the LDR brachytherapy group compared with the HDR group.