International journal of radiation oncology, biology, physics
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Int. J. Radiat. Oncol. Biol. Phys. · Jul 2009
Fractionated stereotactic radiotherapy treatment of cavernous sinus meningiomas: a study of 100 cases.
We discuss our experiences with fractionated stereotactic radiotherapy (FSR) in the treatment of cavernous sinus meningiomas. ⋯ FSR facilitates tumor control, either as an initial treatment option or in combination with microsurgery. In addition to being a safe procedure with few side effects, FSR offers the significant benefit of superior functional outcomes.
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Int. J. Radiat. Oncol. Biol. Phys. · Jul 2009
Hypofractionated intensity-modulated radiotherapy for carcinoma of the prostate: analysis of toxicity.
Dose escalation for prostate cancer improves biological control but with a significant increase in late toxicity. Recent estimates of low alpha/beta ratio for prostate cancer suggest that hypofractionation may result in biological advantage. Intensity-modulated radiotherapy (IMRT) should enable dose escalation to the prostate while reducing toxicity to local organs. We report late toxicity data of a hypofractionated IMRT regime. ⋯ These data demonstrate that hypofractionated radiotherapy using IMRT for prostate cancer is well tolerated with minimal late toxicity at 2 years posttreatment. Ongoing studies are looking at the efficacy of hypofractionated regimes with respect to biological control.
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Int. J. Radiat. Oncol. Biol. Phys. · Jul 2009
Optimal treatment planning for skull base chordoma: photons, protons, or a combination of both?
We compared dosimetry of proton (PR), intensity modulated radiation therapy (IMRT) photon (PH), and combined PR and IMRT PH (PP) irradiation of skull base chordomas to determine the most optimal technique. ⋯ There are dosimetric advantages to using either PH1 or PP plans, with the latter yielding the best target coverage and conformality.
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Int. J. Radiat. Oncol. Biol. Phys. · Jul 2009
Stereotactic body radiotherapy is effective salvage therapy for patients with prior radiation of spinal metastases.
To provide actuarial outcomes and dosimetric data for spinal/paraspinal metastases, with and without prior radiation, treated with stereotactic body radiotherapy (SBRT). ⋯ Spine SBRT has shown preliminary efficacy and safety in patients with image-based progression of previously irradiated metastases.
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Int. J. Radiat. Oncol. Biol. Phys. · Jul 2009
Semiquantitative and quantitative dynamic contrast-enhanced magnetic resonance imaging measurements predict radiation response in cervix cancer.
To evaluate semiquantitative and quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) measurements in predicting the response to radiotherapy in cervix cancer. ⋯ This is the first study to show that pretreatment DCE-MRI quantitative parameters predict the radiation response in cervix cancer. These measurements may allow a more meaningful comparison of DCE-MRI studies from different centers.