International journal of radiation oncology, biology, physics
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Int. J. Radiat. Oncol. Biol. Phys. · Aug 2012
Comparative StudySimilar survival with breast conservation therapy or mastectomy in the management of young women with early-stage breast cancer.
To evaluate survival outcomes of young women with early-stage breast cancer treated with breast conservation therapy (BCT) or mastectomy, using a large, population-based database. ⋯ Our analysis of this population-based database suggests that young women with early-stage breast cancer have similar survival rates whether treated with BCT or mastectomy. These patients should be counseled appropriately regarding their treatment options and should not choose a mastectomy based on the assumption of improved survival.
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Int. J. Radiat. Oncol. Biol. Phys. · Aug 2012
Practice GuidelineRadiotherapy technical considerations in the management of locally advanced pancreatic cancer: American-French consensus recommendations.
Pancreatic carcinoma is a leading cause of cancer-related mortality. Approximately 30% of pancreatic cancer patients present with locally advanced, unresectable nonmetastatic disease. For these patients, two therapeutic options exist: systemic chemotherapy or chemoradiotherapy. ⋯ Radiotherapy quality assurance is mandatory in clinical trials. These consensus recommendations are proposed for use in the development of future trials testing new chemotherapy combinations with radiotherapy. Not all of these recommendations will be appropriate for trials testing radiotherapy dose or dose intensity concepts.
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Int. J. Radiat. Oncol. Biol. Phys. · Aug 2012
Randomized Controlled Trial Comparative StudySkin-sparing helical tomotherapy vs 3D-conformal radiotherapy for adjuvant breast radiotherapy: in vivo skin dosimetry study.
We investigated whether treatment-planning system (TPS)-calculated dose accurately reflects skin dose received for patients receiving adjuvant breast radiotherapy (RT) with standard three-dimensional conformal RT (3D-CRT) or skin-sparing helical tomotherapy (HT). ⋯ The 3D-CRT TPS more accurately reflected skin dose than the HT TPS, which tended to overestimate dose received by 14% in patients receiving adjuvant breast RT.
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Int. J. Radiat. Oncol. Biol. Phys. · Aug 2012
Subclassification of recursive partitioning analysis Class II patients with brain metastases treated radiosurgically.
Although the recursive partitioning analysis (RPA) class is generally used for predicting survival periods of patients with brain metastases (METs), the majority of such patients are Class II and clinical factors vary quite widely within this category. This prompted us to divide RPA Class II patients into three subclasses. ⋯ Our new grading system should be considered when designing future clinical trials involving brain MET patients.
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Int. J. Radiat. Oncol. Biol. Phys. · Aug 2012
Comparative StudyCritical appraisal of Acuros XB and Anisotropic Analytic Algorithm dose calculation in advanced non-small-cell lung cancer treatments.
To assess the clinical impact of the Acuros XB algorithm (implemented in the Varian Eclipse treatment-planning system) in non-small-cell lung cancer (NSCLC) cases. ⋯ The availability of Acuros XB could improve patient dose estimation, increasing the data consistency of clinical trials.