International journal of radiation oncology, biology, physics
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Int. J. Radiat. Oncol. Biol. Phys. · Mar 2006
Supratentorial primitive neuroectodermal tumors (S-PNET) in children: A prospective experience with adjuvant intensive chemotherapy and hyperfractionated accelerated radiotherapy.
Supratentorial primitive neuroectodermal tumors (S-PNET) are rare and have a grim prognosis, frequently taking an aggressive course with local relapse and metastatic spread. We report the results of a mono-institutional therapeutic trial. ⋯ Hyperfractionated accelerated RT was the main tool in obtaining responses in S-PNET; introducing the myeloablative phase improved the prognosis (3/10 vs. 3/5 relapses), though the outcome remained unsatisfactory despite the adoption of this intensive treatment.
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Int. J. Radiat. Oncol. Biol. Phys. · Mar 2006
Cluster model analysis of late rectal bleeding after IMRT of prostate cancer: a case-control study.
Cluster models are newly developed normal-tissue complication probability models in which the spatial aspects of radiation-induced injury are taken into account by considering the size of spatially contiguous aggregates of damaged tissue units. The purpose of this study was to test the validity of a two-dimensional cluster model of late rectal toxicity based on maximum cluster size of damage to rectal surface. ⋯ This study suggests that a cluster model based on maximum cluster size of damage to rectal surface successfully incorporates spatial information beyond that contained in the rectal dose-surface histogram and may therefore provide a useful new tool for predicting rectal normal-tissue complication probability after radiotherapy.
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Int. J. Radiat. Oncol. Biol. Phys. · Mar 2006
Low-grade toxicity after conformal radiation therapy for prostate cancer--impact of bladder volume.
To assess the impact of dose-volume histogram parameters on low-grade toxicity after radiotherapy for prostate cancer. ⋯ The patient's ability to fill the bladder has a major impact on the dose-volume histogram and both acute and late urinary toxicity.
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Int. J. Radiat. Oncol. Biol. Phys. · Mar 2006
Intensity-modulated radiotherapy in high-grade gliomas: clinical and dosimetric results.
To report preliminary clinical and dosimetric data from intensity-modulated radiotherapy (IMRT) for malignant gliomas. ⋯ It is unlikely that IMRT will improve local control in high-grade gliomas without further dose escalation compared with conventional radiotherapy. However, it might result in decreased late toxicities associated with radiotherapy.
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Int. J. Radiat. Oncol. Biol. Phys. · Mar 2006
Multicenter StudyA phase II study of external beam radiotherapy combined with permanent source brachytherapy for intermediate-risk, clinically localized adenocarcinoma of the prostate: preliminary results of RTOG P-0019.
To estimate the rate of acute and late Grade 3-5 genitourinary and gastrointestinal toxicity after treatment with external beam radiotherapy and permanent source brachytherapy in a multi-institutional, cooperative group setting. ⋯ The acute and late morbidity observed in this multi-institutional, cooperative group study is consistent with previous reports from single institutions with significant prostate brachytherapy experience.