Neuroscience
-
The highest disability rates and mortality among neurodegenerative diseases were caused by intracerebral hemorrhage (ICH). We previously proved that Benzene, 1,2,4-trimethoxy-5-(2-methyl-1-propen-1-yl) (BTY) has an inhibitory effect on sodium ion channel and an activation effect on GABAA receptor, which were related to the brain injury. Based on this, we aimed to investigate BTY's neuroprotection on intracerebral hemorrhage and its underlying mechanism. ⋯ The results showed that the BTY reduced brain edema and hematoma volume, improved neurological function and BBB permeability, and inhibited inflammatory factors and neuron apoptosis. The cell experiments proved that the BTY suppressed oxidative stress, cell apoptosis, intracellular calcium influx, and stabilized mitochondrial membrane potential by reducing glutamate's excitotoxicity. This study for the first time exhibited desirable neuroprotection of BTY, indicating it may be a promising neuroprotective agent for ICH therapy.
-
Glioblastoma multiforme (GBM) is the most common cancer in nervous system around the world. Little advancement has been achieved in promoting prognosis of GBM patients. Circular RNAs (circRNAs) are suggested as crucial effectors in modulating GBM development. ⋯ POU3F2 activated the transcription of SOX9 through interacting with SOX9 promoter (1-500). Rescue assays validated that circPOLR2A influenced GBM cell proliferation and apoptosis via SOX9. To conclude, circPOLR2A enhanced the transcription of SOX9 through miR-2113/POU3F2 axis, thus exacerbating GBM cells growth.
-
Everyday creativity is the basic ability of human survival and penetrates every aspect of life. Nevertheless, the neural mechanisms underlying everyday creativity was largely unexplored. In this study, seventy-five participants completed the creative behaviour inventory, a tool for assessing creative behaviour in daily life. ⋯ Interestingly, individual differences in everyday creativity were associated with distinct patterns of EEG alpha activity. Specifically, individuals with higher everyday creativity had increased alpha power in the frontal cortex, and increased changes in coherence in frontal-temporal regions of the right hemisphere while performing the AUT. It might indicate that individuals with higher everyday creativity had an enhanced ability to focus on internal information processing and control bottom-up stimuli, as well as better selection of novel semantic information when performing creative ideation tasks.
-
The inflammatory response of central nervous system (CNS) and microglial activation is important in the development of pain behaviors induced by sleep deprivation. We found that chronic sleep deprivation (CSD) aggravated pain behaviors in rats with chronic pain by upregulating expression of Toll-like receptor 4 (TLR4), NOD-like receptor pyrin domain containing 3 (NLRP3), and interleukin 1β (IL-1β), which promoted microglial activation in the brain. ⋯ Inhibitors of TLR4 and NLRP3 (TAK-242 and MCC950, respectively) reduced expression levels of inflammatory factor proteins and M1-related factor mRNA, decreased microglial activation, and relieved the hyperalgesia caused by CSD. These results suggest that CSD aggravated pain behavior in rats with chronic pain through the TLR4/NLRP3/IL-1β signaling pathway, which mediates microglial activation and promotes CNS inflammation and neuronal apoptosis.
-
Some studies have argued that the dorsal anterior cingulate cortex (dACC) is generally activated in response to aversive information, including pain, negative affect, and cognitive conflict. Other studies have claimed that the dACC has subdivisions, and each division has a specific function. By manipulating emotionally and cognitively aversive cues, the present study determined whether the dACC is generally responsive to aversiveness or it has subdivisions for specific forms of aversiveness. ⋯ We also found that the superior part of the dACC was uniquely activated in response to cognitively aversive cues, partially supporting the functional segregation account. Collectively, our results provide evidence that the specific locus of the dACC is generally responsive to distinctive motivational information, whereas the other loci may have segregated functions. Discussion includes recent neurocomputational theories that seem to satisfactorily account for the present results.