Neuroscience
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With the increased availability and sophistication of digital devices in the last decade, young people have become mainstream mobile phone users. Heavy mobile phone dependence causes affective problems (depression, anxiety) and loss of attention on current activities, leading to more cluttered thoughts. Problematic mobile phone use has been found to increase the occurrence of mind wandering, but the neural mechanism underlying this relationship remains unclear. ⋯ FC between the frontoparietal and motor networks, between the default mode network and cerebellar network, and within the cerebellar network mediated the relationship between mobile phone addiction and mind wandering. The findings confirm that mobile phone addiction is a risk factor for increased mind wandering and reveal that FC in several brain networks underlies this relationship. They contribute to research on behavioral addiction, education, and mental health among young adults.
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Essential tremor with resting tremor (rET) and tremor-dominant Parkinson's disease (tPD) share many similar clinical symptoms, leading to frequent misdiagnoses. Functional connectivity (FC) matrix analysis derived from resting-state functional MRI (Rs-fMRI) offers a promising approach for early diagnosis and for exploring FC network pathogenesis in rET and tPD. However, methods relying solely on a single connection pattern may overlook the complementary roles of different connectivity patterns, resulting in reduced diagnostic differentiation. ⋯ Compared with single-pattern GCN, our proposed MCGCN model demonstrated superior classification accuracy, underscoring the advantages of integrating multiple connectivity modes. Specifically, the model achieved an average accuracy of 88.0% for distinguishing rET from HC, 88.8% for rET from tPD, and 89.6% for tPD from HC. Our findings indicate that combining graph convolutional networks with multi-connection patterns can not only effectively discriminate between tPD, rET, and HC but also enhance our understanding of the functional network mechanisms underlying rET and tPD.
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Cellular senescence is involved in the progression of neurodegenerative diseases. Motor neurons exhibit senescence-like alterations in ALS. BRD7, identified as a regulatory factor associated with cellular senescence, its function in ALS remains unclear. ⋯ Knockdown of BRD7 inhibited p53 mitochondrial translocation, leading to reduced apoptosis. Our results suggest that BRD7 plays an important role in the survival of ALS motor neurons. BRD7 knockdown can reduce cellular senescence and apoptosis by inhibiting p21 and p53 mitochondrial translocation.
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A common anatomical core has been described for psychiatric disorders, consisting of the dorsal anterior cingulate cortex (dACC) and anterior insula, processing uncertainty. A common neurophysiological core has been described for other brain related disorders, called thalamocortical dysrhythmia (TCD), consisting of persistent cross-frequency coupling between low and high frequencies. And a common genetic core has been described for yet another set of hypodopaminergic pathologies called reward deficiency syndromes (RDS). ⋯ TCD and RDS share a common anatomical and neurophysiological core, consisting of beta activity in the dACC and theta activity in dACC extending into precuneus and dorsolateral prefrontal cortex. TCD and RDS differ in pgACC/vmPFC activity and demonstrate an opposite balance between pgACC/vmPFC and dACC. Based on the Bayesian brain model TCD and RDS can be defined as uncertainty disorders in which the pgACC/vmPFC and dACC have an opposite balance, possibly explained by an inverted-U curve profile of both pgACC/vmPFC and dACC.
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To investigate the characteristics and diagnostic values of the eye movement disorders in patients with Parkinson's disease (PD-EMDs), this cross-sectional study enrolled 127 Chinese patients with PD and 80 healthy controls, and divided them into training and validation sets based on enrollment time. Performance in the five oculomotor paradigms was assessed using an infrared pupil and a corneal reflection tracking device. The primary characteristics of PD-EMDs were elucidated as inaccurate fixation with high deviation (frequency and total quantity); inaccurate saccades with delayed reaction and low velocity; saccadic pursuit with high deviation, delayed reaction, and velocity; and decreased visual search ability. ⋯ The model has good feasibility with satisfactory performance on the receiver operating characteristic, calibration, and decision curves, and broad clinical applicability with better discrimination for more advanced PD patients and non-tremor-dominant PD patients. A nomogram was created to make the model more user-friendly in the clinical setting. Overall, we have demonstrated the presence of PD-EMDs and their prospective value for PD preliminary screening.