Clinical and experimental dermatology
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Clin. Exp. Dermatol. · Sep 2006
Case ReportsA case of a Japanese neonate with congenital ichthyosiform erythroderma diagnosed as Netherton syndrome.
We report a 6-day-old Japanese girl showing generalized erythroderma accompanied by yellowish, exfoliative scaling that was accentuated on the face and scalp. Histological analysis showed psoriasiform dermatitis with acanthotic epidermis and premature shedding of the stratum corneum. ⋯ DNA analysis revealed two mutations, 375delAT and 966insC, in exons 5 and 11, respectively, of the SPINK5 gene. Although at 4 weeks the child was still too young to display characteristic hair abnormalities or atopic diathesis, we diagnosed Netherton syndrome based on enzyme assay and DNA analysis.
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Clin. Exp. Dermatol. · Sep 2006
Appropriateness of prescribing for childhood eczema: evidence from a community-based study.
Data on dispensed prescriptions of topical corticosteroids and emollients were analysed in a population of 25 484 children aged