Clinical and experimental dermatology
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Clin. Exp. Dermatol. · Mar 2008
Effects of asiaticoside on the expression of Smad protein by normal skin fibroblasts and hypertrophic scar fibroblasts.
The precise mechanism of asiaticoside in molecular and gene expression levels of Smad protein and mRNA still remains unknown. We hypothesised that asiaticoside might inhibit the formation of hypertrophic scarring by affecting the expression of Smad protein and interfering with the Smad signalling pathway. ⋯ Asiaticoside inhibits scarring probably by enhancing the expression of inhibitory Smad7, and is a potential treatment for scarring.
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Clin. Exp. Dermatol. · Mar 2008
Case ReportsSubcutaneous sarcoidosis localised to sites of previous desensitizing injections.
Subcutaneous sarcoidosis is a specific cutaneous lesion of systemic sarcoidosis that is rarely reported. Clinically, it is characterized by multiple, asymptomatic subcutaneous nodules mainly located on the forearms. ⋯ Nodular lesions may also develop at the site of injection; these have been attributed to the aluminium hydroxide contained by many vaccines. We report a 49-year old woman with a history of two outbreaks of acute sarcoidosis (Löfgren syndrome) in 1994 and 1999, who developed lesions of subcutaneous sarcoidosis in the upper part of both arms, at the sites of desensitization injections for extrinsic asthma immunotherapy.