Clinical and experimental dermatology
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Clin. Exp. Dermatol. · Dec 2013
Case ReportsDermatitis artefacta in a vulnerable adult with a dissociative state.
Dermatitis artefacta (DA), a factitious skin disorder, often occurs as a response to traumatic life events or as a factitious behaviour, which may result in secondary gain. It can be difficult to get patients to engage with health services, and they seldom admit to causing the lesions themselves. ⋯ We present a case of DA diagnosed in a vulnerable adult, who we believe caused the lesions during periods of dissociation. We discuss the way in which the concept of dissociation can provide an acceptable way of discussing the behaviour with patients and initiating psychological therapy.
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Clin. Exp. Dermatol. · Dec 2013
Meta AnalysisAssociation of the tumour necrosis factor-α polymorphisms rs361525 and rs1800629 with susceptibility to psoriasis: a meta-analysis.
Evidence has suggested that tumour necrosis factor (TNF)-α may be involved in the aetiology of psoriasis, but the underlying association of the TNF-α polymorphisms -238G/A (rs361525) and -308G/A (rs1800629) with the risk of psoriasis is still unconfirmed. ⋯ This meta-analysis suggests that the TNF-α -238 and -308 promoter polymorphisms may play different roles in conferring susceptibility to psoriasis. Functional and well-designed studies should be conducted to confirm these results.