Archives of pathology & laboratory medicine
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Arch. Pathol. Lab. Med. · Dec 2008
Review Case ReportsSister Mary Joseph nodule as a first and only sign of extraovarian carcinoma: a case report and review of the literature.
Sister Mary Joseph nodule is one of the less well-known signs of intra-abdominal metastatic disease. The primary tumor site is nearly always detected because of specific morphologic and immunohistochemical features of the umbilical tumor. ⋯ Despite an extensive workup, no primary tumor could be detected and therefore we ultimately diagnosed the tumor as an extraovarian carcinoma with primary site at the umbilicus. After a literature search we concluded that a primary adenocarcinoma of the umbilicus is extremely rare and to our knowledge has never been described with both morphologic and immunohistochemical features of a serous ovarian carcinoma.