Archives of pathology & laboratory medicine
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Arch. Pathol. Lab. Med. · Jan 2010
ReviewHigh-resolution computed tomography screening for lung cancer: unexpected findings and new controversies regarding adenocarcinogenesis.
Recent advances in human imaging technologies reawakened interest in lung cancer screening. Although historic and current preliminary and noncontrolled studies have not shown a decrease in lung cancer mortality in screened populations, many explanations have been proffered while the lung cancer community awaits the results of several large controlled population studies. ⋯ The current adenocarcinogenesis model is probably valid for many but not all lung adenocarcinomas. Screening data combined with radiographic and pathologic studies suggest that not all lung adenocarcinomas are clinically aggressive, and it is uncertain whether all aggressive adenocarcinomas arise from identified precursors.