Archives of pathology & laboratory medicine
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Arch. Pathol. Lab. Med. · Sep 2014
Case Reports Comparative StudyMegakaryocytic morphology and clinical parameters in essential thrombocythemia, polycythemia vera, and primary myelofibrosis with and without JAK2 V617F.
Megakaryocytes are the "hallmark" of Philadelphia chromosome-negative myeloproliferative neoplasms, such as essential thrombocythemia, polycythemia vera, and primary myelofibrosis; their morphology in correlation with Janus kinase 2 (JAK2 V617F) mutation as well as clinical and laboratory parameters remains unknown. ⋯ Our results indicate that primary myelofibrosis JAK2 V617F and polycythemia vera JAK2 V617F share pathogenetic pathways, resulting in morphologically similar megakaryocytes.
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Arch. Pathol. Lab. Med. · Sep 2014
Multicenter Study Comparative StudyTrends in parenteral direct thrombin inhibitor use in pediatric patients: analysis of a large administrative database.
Parenteral direct thrombin inhibitors (DTIs) may be used in pediatric patients with contraindications to heparin therapy, such as heparin-induced thrombocytopenia. Few data exist regarding the use of DTIs in pediatric patients. ⋯ Pediatric use of DTIs is infrequent and occurs in patients with high morbidity and mortality.