Clinical neuropharmacology
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Clin Neuropharmacol · Jul 2005
Randomized Controlled TrialBotulinum toxin and intractable trigeminal neuralgia.
The effects of botulinum toxin have been demonstrated in pain syndromes such as migraine, tension headache, and postherpetic neuralgia. With this background data in hand, the authors planned a randomized, open-ended study to investigate the efficacy of botulinum injections in cases of refractory trigeminal neuralgia. ⋯ The patients did not develop any significant adverse effects. Botulinum toxin can be used in the treatment of refractory trigeminal neuralgia.