Clinical neuropharmacology
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Clin Neuropharmacol · Sep 2006
Randomized Controlled Trial Comparative Study Clinical TrialTopiramate and triptans revert chronic migraine with medication overuse to episodic migraine.
This is a randomized, double-blind versus placebo study aimed at evaluating the efficacy of topiramate (TPM) in reducing the number of days with headache and the amount of acute medication taken monthly in patients with chronic migraine with medication overuse. We also studied the efficacy of single triptans available in Italy in interrupting headache crises during preventive treatment. ⋯ Topiramate proved to be well tolerated and effective in reverting chronic migraine with medication overuse to episodic migraine.