Clinical neuropharmacology
-
Clin Neuropharmacol · Jul 2010
Case ReportsTreatment of chronic akinetic mutism with atomoxetine: subtraction analysis of brain f-18 fluorodeoxyglucose positron emission tomographic images before and after medication: a case report.
Akinetic mutism is a rare, complex neuropathologic disorder. The pharmaceutical treatment of akinetic mutism typically includes dopaminergic agents, but the resulting therapeutic effects are often unsatisfactory, and it remains unclear whether late treatment using these medications is effective. We present a case study of a 53-year-old male patient who developed akinetic mutism for a period of 7 months after a subarachnoid hemorrhage. ⋯ Treatment with atomoxetine, a selective norepinephrine reuptake inhibitor, for a period of 8 weeks led to a clinically significant improvement in the patient's cognitive function and activities of daily living. A subtraction brain positron emission tomographic analysis after atomoxetine medication revealed increased cerebral glucose metabolism in both the premotor and visual association cortices. Thus, we suggest that atomoxetine can be a useful therapeutic option in the treatment of chronic akinetic mutism.
-
Clin Neuropharmacol · Jul 2010
Gabapentin in the treatment of hiccups in patients with advanced cancer: a 5-year experience.
To evaluate safety and efficacy of gabapentin in the treatment of severe chronic hiccups in patients with advanced cancer. ⋯ The results of the study allow suggesting gabapentin at least as a promising drug in the treatment of severe chronic hiccups in advanced cancer patients.
-
Clin Neuropharmacol · Jul 2010
Letter Case ReportsPosthypoxic myoclonus (Lance-Adams syndrome) treated with lacosamide.