Clinical neuropharmacology
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Clin Neuropharmacol · Sep 2005
Randomized Controlled TrialDrug-induced psychosis in Parkinson disease: phenomenology and correlations among psychosis rating instruments.
To describe further the phenomenology of drug-induced psychosis (DIP) in patients with Parkinson disease (PD) and assess which items on two common psychosis rating instruments-the Brief Psychiatric Rating Scale (BPRS) and the Neuropsychiatric Inventory (NPI)-are the best measure of DIP by comparing them with the Clinical Global Impression Scale (CGIS). ⋯ Nonvisual hallucinations and delusions may occur more frequently in DIP than previously thought. These symptoms, plus agitation and hostility, may ultimately be the best measure of DIP in patients with PD.
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Clin Neuropharmacol · Jul 2005
Randomized Controlled TrialBotulinum toxin and intractable trigeminal neuralgia.
The effects of botulinum toxin have been demonstrated in pain syndromes such as migraine, tension headache, and postherpetic neuralgia. With this background data in hand, the authors planned a randomized, open-ended study to investigate the efficacy of botulinum injections in cases of refractory trigeminal neuralgia. ⋯ The patients did not develop any significant adverse effects. Botulinum toxin can be used in the treatment of refractory trigeminal neuralgia.
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Clin Neuropharmacol · Jul 2004
Randomized Controlled Trial Comparative Study Clinical TrialRopinirole as a treatment of restless legs syndrome in patients on chronic hemodialysis: an open randomized crossover trial versus levodopa sustained release.
Restless legs syndrome (RLS) is a common neurologic condition characterized by uncomfortable and unpleasant sensations in the legs, occurring primarily at rest, which are usually worse in the evening and are alleviated by movement. RLS is present in 20-40% of patients with renal failure. This study was a 14-week open, randomized, crossover trial of ropinirole vs. levodopa sustained release (SR) in 11 patients with RLS on chronic hemodialysis. ⋯ These results suggest that ropinirole is more effective than levodopa SR in the treatment of RLS in patients on chronic hemodialysis.
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Clin Neuropharmacol · Jul 2004
Randomized Controlled Trial Comparative Study Clinical TrialIntravenous subhypnotic propofol in central pain: a double-blind, placebo-controlled, crossover study.
To validate IV subhypnotic propofol, a gamma-aminobutyric acid A (GABA-A) agonist, as a diagnostic test for central pain. ⋯ Systemic propofol induces analgesic effects on all studied components of central pain and highlights the key role of GABA modulation in central pain.
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Clin Neuropharmacol · Mar 2004
Randomized Controlled Trial Clinical TrialEffects of modafinil on wakefulness and executive function in patients with narcolepsy experiencing late-day sleepiness.
A modafinil daily dosing strategy promotes wakefulness in narcolepsy patients experiencing excessive daytime sleepiness; however, some patients may continue to experience late-day sleepiness. Excessive sleepiness in narcolepsy is associated with cognitive impairment. Modafinil has improved executive function in other models of excessive sleepiness. This study evaluated the effects of once-daily vs. split doses of modafinil on wakefulness and of combined doses on executive function in narcolepsy patients experiencing late-day sleepiness despite satisfactory modafinil treatment earlier in the day. ⋯ For patients with residual late-day sleepiness associated with narcolepsy, an additional 200-mg dose of modafinil taken at midday was effective in sustaining wakefulness throughout the entire waking day. Treatment with modafinil also significantly improved executive function.