Psychopharmacology
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Randomized Controlled Trial Comparative Study Clinical Trial
St John's wort extract (LI 160) in somatoform disorders: results of a placebo-controlled trial.
Preliminary data have shown that St John's wort might possess some specific efficacy in patients with somatoform complaints. Therefore, the efficacy of the Hypericum extract LI 160 in patients with somatoform disorders should be studied in a double-blind placebo-controlled fashion. ⋯ The data from this trial show excellent efficacy and tolerability for LI 160 in somatoform disorders. The efficacy is independent of an existing depressive mood. This is the first study showing the efficacy of a drug in patients with somatisation disorder independent of depressive symptomatology.
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Randomized Controlled Trial Comparative Study Clinical Trial
Smokers deprived of cigarettes for 72 h: effect of nicotine patches on craving and withdrawal.
Research on the effects of nicotine abstinence and nicotine replacement has not provided consistent information about the impact of replacement therapies on tobacco withdrawal and craving. ⋯ The data suggested that craving and withdrawal symptoms may be sustained by different physiological pathways, and that only selected components of cigarette craving are influenced by NRT.