Psychopharmacology
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Randomized Controlled Trial Comparative Study Clinical Trial
Interaction between naltrexone and oral THC in heavy marijuana smokers.
Studies in non-human animals suggest that opioid antagonists block the reinforcing effects of cannabinoids. ⋯ These studies demonstrate that naltrexone increases the subjective effects of oral THC. Thus, oral THC's effects are enhanced rather than antagonized by opioid receptor blockade in heavy marijuana smokers.