The American journal of sports medicine
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Widespread adoption of fresh allograft transplantation remains limited, predominantly by supply issues. To overcome these limitations, a preshaped, cylindrical sterilized and decellularized osteochondral allograft (SDOCA) implant was recently introduced as a clinical treatment option. ⋯ The SDOCA implant demonstrated a 72% failure rate within the first 2 years of implantation at these 2 institutions.
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A special type of meniscal lesion involving the peripheral attachment of the posterior horn of the medial meniscus (PHMM), termed ramp lesion, is commonly associated with anterior cruciate ligament (ACL) injury. However, no study has investigated its anatomic risk factors. Recently, increased meniscal slope has been identified as an independent anatomic risk factor for noncontact ACL injury. ⋯ Increased MMS was identified to be an independent anatomic risk factor of concomitant ramp lesions in noncontact ACL injuries, particularly for those with a TFI ≥6 months. This may provide additional information for counseling patients who have increased MMS on the greater risk of secondary PHMM lesions if their ACL-deficient knee joints are not well stabilized initially.
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Platelet-rich plasma (PRP) is now widely used as a promising treatment for patients with tendinopathy. However, the efficacy of PRP treatment for tendinopathy is controversial mainly because of inconsistent results from human clinical trials and particularly because the concentration and effect of leukocytes in PRP remain largely unknown. ⋯ This study revealed the direct effects of different compositions of PRP on TSCs and provided basic scientific data to help understand the cellular and molecular mechanisms of the efficacy of PRP treatment in clinical use.