Neuropathology and applied neurobiology
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Neuropathol. Appl. Neurobiol. · Oct 1993
Leucotomized schizophrenics lose neurons in the mediodorsal thalamic nucleus.
It has previously been shown that chronic schizophrenic patients have a 40-50% reduction in the total number of nerve and glia cells in the mediodorsal thalamic nucleus and the nucleus accumbens compared with controls, while the total neuron and glia number is the same in the two groups in the ventral pallidum. Using new stereological cell counting methods, neuron and glia cell numbers were estimated in the mediodorsal thalamic nucleus, the ventro-medial part of nucleus accumbens and the ventral pallidum in nine brains from leucotomized schizophrenics. This number was compared with counts from control cases and chronic schizophrenics without leucotomy. ⋯ The total neuron number in ventral pallidum was normal. With frontal leucotomy it is possible to investigate the consequences of disconnection of the prefrontal cortex to central regions in the human brain. The mediodorsal nucleus of thalamus represents a major efferent projection to the prefrontal cortex.(ABSTRACT TRUNCATED AT 250 WORDS)