Neuropathology and applied neurobiology
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Neuropathol. Appl. Neurobiol. · Oct 2015
ReviewMolecular and cellular pathogenesis of adamantinomatous craniopharyngioma.
Adamantinomatous craniopharyngiomas (ACPs) are the most common pituitary tumours in children. Although histologically benign, these are clinically aggressive tumours, difficult to manage and associated with poor quality of life for the patients. ⋯ As the result of this basic research, the pathogenesis of ACP is being unveiled, with promising implications for the development of novel treatments against these childhood neoplasms. These benign tumours may additionally represent a unique model to provide insights into the initial steps of oncogenesis.