Spine
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Based on the experimental and clinical results in the literatures and the author's experience, a working hypothesis for the pathomechanism of radicular pain is proposed. When the nerve root is involved, mechanical and circulatory changes are produced. ⋯ Disturbed or enhanced synthesis and transport of neuropeptides can also be elicited. These multifactorial changes may finally result in sensitization of both the central and peripheral nervous systems, causing radicular pain.