Spine
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Comparative Study
Effects of charité artificial disc on the implanted and adjacent spinal segments mechanics using a hybrid testing protocol.
Finite element model of L3-S1 segment and confirmatory cadaveric testing were used to investigate the biomechanical effects of a mobile core type artificial disc (Charité artificial disc; DePuy Spine, Raynham, MA) on the lumbar spine. ⋯ The hybrid testing protocol is advocated because it better reproduces clinical observations in terms of motion following surgery, using pure moments. Using this approach, we found that the Charité artificial disc placement slightly increases motion at the implanted level, with a resultant increase in facet loading when compared to the adjacent segments, while the motions and loads decrease at the adjacent levels. However, in the load control mode that we believe is not that clinically relevant, there was a large increase in motion and a corresponding increase in facet loads, as compared to the intact.
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Randomized Controlled Trial Multicenter Study Comparative Study
The treatment of disc herniation-induced sciatica with infliximab: results of a randomized, controlled, 3-month follow-up study.
A randomized controlled trial. ⋯ The results of this randomized trial do not support the use of infliximab for lumbar radicular pain in patients with disc herniation-induced sciatica.
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Comparative Study
Biomechanical assessment of the pediatric cervical spine under bending and tensile loading.
Cadaveric head-neck complexes from pediatric donors aged 2-12 years were subjected to a test battery consisting of nondestructive flexion-extension bending, nondestructive tensile step-and-hold tests, and tensile distraction loading to failure. ⋯ The current study provides valuable new information on the response and tolerance of the pediatric cervical spine to quasi-static flexion-extension and tensile distraction loading.
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Case Reports
Acute intracranial subdural hematoma following a lumbar CSF leak caused by spine surgery.
Case report. ⋯ We report the rare case of an acute intracranial subdural hematoma caused by a CSF leak following lumbar surgery. This report illustrates the potential morbidity associated with CSF leaks occurring after spinal surgery.
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Comparative Study
Ischemic injury-specific gene expression in the rat spinal cord injury model using hypoxia-inducible system.
A spinal cord injury and in vitro neural hypoxia models were used to evaluate the hypoxia responsive gene expression. ⋯ The pEpo-SV-Luc and pRTP801-Luc systems are effective in that they induce gene expression specifically in neurons under the hypoxic condition and spinal cord injury.