Spine
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Randomized Controlled Trial Multicenter Study Comparative Study
Comparison of OP-1 Putty (rhBMP-7) to iliac crest autograft for posterolateral lumbar arthrodesis: a minimum 2-year follow-up pilot study.
A prospective, randomized, controlled, multicenter clinical study. ⋯ This study represents the first clinical trial to demonstrate the safety and similarity of OP-1 Putty as a replacement for autogenous bone graft in the posterolateral fusion environment with a minimum of 2-year follow-up. OP-1 Putty was able to achieve osteoinduction leading to a radiographically solid fusion in the absence of autogenous iliac crest bone graft in 55% of the patients at 24 and 36 months. These results compare favorably to the historical fusion rates reported for uninstrumented arthrodesis in this challenging clinical scenario.
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Randomized Controlled Trial Multicenter Study Comparative Study
The treatment of disc herniation-induced sciatica with infliximab: results of a randomized, controlled, 3-month follow-up study.
A randomized controlled trial. ⋯ The results of this randomized trial do not support the use of infliximab for lumbar radicular pain in patients with disc herniation-induced sciatica.
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Randomized Controlled Trial Comparative Study
Predictors and modifiers of treatment effect influencing sick leave in subacute low back pain patients.
Modifying effects in multivariate analyses of a randomized controlled trial. ⋯ The spine clinic intervention seems to have a main effect on work absenteeism via interacting with the concerns of being unable to work.