Spine
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Postoperative outcomes of cervical pedicle screw (CPS) placement were evaluated. The screws were inserted in degenerative vertebrae using anatomic landmarks. ⋯ The deviation rate of CPS placement using anatomic landmarks was higher than anticipated, although no serious complications were encountered. Refinement of the technique (e.g., using a computer-assisted navigation system) is strongly recommended.
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Comparative Study
Ischemic injury-specific gene expression in the rat spinal cord injury model using hypoxia-inducible system.
A spinal cord injury and in vitro neural hypoxia models were used to evaluate the hypoxia responsive gene expression. ⋯ The pEpo-SV-Luc and pRTP801-Luc systems are effective in that they induce gene expression specifically in neurons under the hypoxic condition and spinal cord injury.
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Comment Letter Comparative Study
Interspinous process decompression system (X STOP) device affords superior outcomes and equal safety to nonoperative therapy.
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Randomized Controlled Trial Multicenter Study Comparative Study
Comparison of OP-1 Putty (rhBMP-7) to iliac crest autograft for posterolateral lumbar arthrodesis: a minimum 2-year follow-up pilot study.
A prospective, randomized, controlled, multicenter clinical study. ⋯ This study represents the first clinical trial to demonstrate the safety and similarity of OP-1 Putty as a replacement for autogenous bone graft in the posterolateral fusion environment with a minimum of 2-year follow-up. OP-1 Putty was able to achieve osteoinduction leading to a radiographically solid fusion in the absence of autogenous iliac crest bone graft in 55% of the patients at 24 and 36 months. These results compare favorably to the historical fusion rates reported for uninstrumented arthrodesis in this challenging clinical scenario.