Spine
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Comparative Study
Biomechanical analysis of posterior fixation techniques in a 360 degrees arthrodesis model.
A biomechanical study to assess the ability of posterior fixation techniques to stabilize a functional spine unit (FSU) after insertion of an anterior load-sharing device. ⋯ Using a load-sharing interbody implant, translaminar facet screws are equivalent to bilateral pedicle screws in resisting motion in all three planes. Translaminar facet screws and bilateral pedicle screws offer greater stabilization in all three planes compared with unilateral pedicle screws and a single plate.
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Comparative Study
Human anulus fibrosis and nucleus pulposus cells of the intervertebral disc: effect of degeneration and culture system on cell phenotype.
Human intervertebral disc cells were harvested from patients with adolescent idiopathic scoliosis (AIS) and from donors with degenerative disc disease. Anulus fibrosis (AF) was separated from nucleus pulposus (NP), and cells were cultured separately in two different cell culture models. ⋯ These results provide a better understanding of how the phenotype of human healthy and degenerative disc cells is influenced by in vitro expansion. This may be useful for future tissue engineering purposes.
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Pinch motion between the thumb and the index finger in myelopathy hand was analyzed using micro-reflective markers and the VICON system. ⋯ Overall, the patients with myelopathy hand exhibited a larger flexion angle in the two distal finger joints when pinching small objects.
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Case Reports
Acute intracranial subdural hematoma following a lumbar CSF leak caused by spine surgery.
Case report. ⋯ We report the rare case of an acute intracranial subdural hematoma caused by a CSF leak following lumbar surgery. This report illustrates the potential morbidity associated with CSF leaks occurring after spinal surgery.
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Comparative Study
De novo osteogenesis from human ligamentum flavum by adenovirus-mediated bone morphogenetic protein-2 gene transfer.
In vitro and in vivo experiment using degenerated human ligamentum flavum (LF) and Type 5 adenovirus construct with bone morphogenetic protein-2 (BMP-2) cDNA. ⋯ Human LF cells transduced with Ad/BMP-2 exhibited the expression of osteogenic phenotype and bone nodule formation. Additionally, genetically modified human LF with BMP-2 cDNA clearly demonstrated de novo osteogenesis, which supports the concept that biologically modified LF can be a substitute for autogenous bone graft in spinal fusion surgery.