Spine
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Comparative Study
The sensitivity and specificity of electrodiagnostic testing for the clinical syndrome of lumbar spinal stenosis.
Prospective, masked, double controlled diagnostic trial. ⋯ This first masked study in the 60-year history of needle electromyography also introduces anatomically validated needle placement, quantified and reproducible examination of the paraspinal muscles, and dual control populations to EDX research in spinal disorders. EDX has statistically significant, clinically meaningful specificity for spinal stenosis and detects neuromuscular diseases that may masquerade as stenosis.
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Comparative Study
Correlation of HR-MAS spectroscopy derived metabolite concentrations with collagen and proteoglycan levels and Thompson grade in the degenerative disc.
A quantitative high-resolution magic angle spinning (HR-MAS) NMR study of human lumbar discs was conducted to determine biomarkers of disc degeneration. ⋯ Changes in disc chemical composition can be accurately quantified using quantitative HR-MAS NMR spectroscopy ex vivo. This noninvasive method of qualitatively and quantitatively assessing disc degeneration supports the utility of these biomarkers and underlines the need for developing in vivo magnetic resonance spectroscopic imaging (MRSI) for characterizing intervertebral disc degeneration.
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Comparative Study
Symptomatic and asymptomatic movement coordination of the lumbar spine and hip during an everyday activity.
This experimental study analyzed the movements of the lumbar spine and hip while putting on a sock. ⋯ Changes in the lumbar and hip kinematics when putting on a sock were related to back pain and limitation in SLR. Low back pain will affect lumbar-hip coordination.
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Comparative Study
Multilevel spinal growth modulation with an anterolateral flexible tether in an immature bovine model.
A bovine model was used to evaluate the effects of a multilevel anterolateral flexible tether in a growing spine. ⋯ Given adequate bony fixation, a flexible lateral spinal tether can affect growth modulation. This technique of growth modulation may serve as a future fusionless method of correction in a growing patient with scoliosis.
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Comparative Study
Effect of recombinant human bone morphogenetic protein-2 in an experimental model of spinal fusion in a radiated area.
An animal model of posterolateral intertransverse process spine fusion was used. ⋯ Use of rhBMP-2 produced a significantly greater rate of fusion compared with ICBG in a previously radiated area in an animal model, without the morbidity of ICBG harvesting and without the risk of inadvertently using autograft contaminated by micrometastases.