Spine
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Clinical, biochemical, and histologic analysis was performed after in vivo delivery of cDNA encoding various anabolic cytokines and marker genes to the lumbar epidural space of New Zealand white rabbits, using both adenoviral and adeno-associated viral vectors. ⋯ Properly dosed and directed gene therapy seems to be both safe and potentially efficacious. This study suggests that side effects of gene therapy may be due to a combination of dosing, transgene product, and vector choice, and that newer AAV vectors may reduce these side-effects and decrease the risk of this technology.
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Multicenter Study Clinical Trial
Vertebral coplanar alignment: a standardized technique for three dimensional correction in scoliosis surgery: technical description and preliminary results in Lenke type 1 curves.
Prospective multicentric study. ⋯ VCA provided excellent correction of coronal and transverse planes with normalization of thoracic kyphosis in Lenke type 1 adolescent idiopathic scoliosis surgery.
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A reliability assessment of standardized magnetic resonance imaging (MRI) interpretations and measurements. ⋯ The imaging characteristics of spinal stenosis assessed in this study showed moderate to substantial reliability; future studies should assess whether these findings have prognostic significance in SPS patients.
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Comparative Study
Standing balance and sagittal plane spinal deformity: analysis of spinopelvic and gravity line parameters.
Prospective study of 131 patients and volunteers recruited for an analysis of spinal alignment and gravity line (GL) assessment by force plate analysis. ⋯ Increasing SVA in standing subjects leads to a posterior pelvic shift in relation to the feet. However, no significant difference in GL-heel offset is noted with increasing SVA. It thus appears that pelvic shift (in relation to the feet) is an important component in maintaining a rather fixed GL-Heels offset even in the setting of variable SVA and trunk inclination.
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Retrospective cohort study. ⋯ Initial CT imaging identified all unstable cervical spine injuries in obtunded trauma patients. Subsequent upright radiographs did not identify any additional injuries but significantly delayed spine clearance.