Spine
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Cross-cultural validation of the Neck Disability Index (NDI) and Neck Pain and Disability Scale (NPDS). ⋯ The NDI-TH and NPDS-TH seem to be reliable instruments to measure functional limitation and disability in Thai patients with neck pain. However, further research is still needed to determine responsiveness and validity of these questionnaires.
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A retrospective analysis was performed. ⋯ Unlike primary aneurysmal bone cyst, secondary aneurysmal bone cyst arising from giant cell tumor of the mobile spine has a more aggressive tendency to recurrence locally. Complete resection with systematic radiotherapy should be undertaken for the treatment of aneurysmal bone cyst secondary to giant cell tumor of the mobile spine, which is associated with a good prognosis for local tumor control. As complete or as radical an operation as possible should be performed at first presentation. The best chance for the patient is the first chance. Selective preoperative embolization is advised to minimize intraoperative blood loss.
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A retrospective longitudinal observational study using baseline and follow-up magnetic resonance imaging (MRI). ⋯ Radial tears and herniation are significant predictors of progressive nuclear degeneration, which was not seen in the absence of radial tears. End plate defects also frequently occur before nuclear degeneration but rarely in the absence of anular tears.
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Retrograde neurotracing and immunohistochemical investigation of brain-derived neurotrophic factor (BDNF)-related sensory innervation of punctured lumbar intervertebral discs (IVDs) in rat dorsal root ganglia (DRG). ⋯ Direct intradiscal application of the anti-BDNF antibody significantly suppressed both CGRP production and the local concentration of BDNF. Our results indicate a possible association between the local production of BDNF and the pathophysiology of discogenic pain.