Spine
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Controlled, interventional, animal study. ⋯ HMGB1 appears to play an important role in the development of pain-related behavior induced by the application of nucleus pulposus onto the DRG. HMGB1 from applied nucleus pulposus and actively secreted from macrophages would act as a proinflammatory mediator together with proinflammatory cytokines. HMGB1 blocking therapy might become a new treatment method for neuropathic pain.
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Historical Article
2010 ISSLS presidential address: juvenile low back pain: some reflections.
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Review Case Reports
Symptomatic vertebral artery compression by the rod of a C1-C2 posterior fusion construct: case report and review of the literature.
Case report. ⋯ In atlantoaxial fusion, the incidence of vertebral artery compression by the rod component of fusion construct may be underreported because it is difficult to detect with noncontrast computed tomography without computed tomographic angiography, which is not routinely obtained unless there is a high suspicion for vascular injury. We recommend inserting the rods with the cut (sharp) end pointing inferiorly, to avoid lacerating the vertebral artery. A vertebral artery compression from the rod in the absence of screw violation of the foramen transversarium should be considered in a patient with altered mental status after atlantoaxial fusion.
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Review Case Reports
Bilateral traumatic dislocation without fracture of the lumbosacral junction: case report and review of the literature.
Case report. ⋯ A careful clinical examination and imaging assessment must be done for appropriate diagnosis and treatment of this rare type of injury. Reduction in the face of intact articulating processes and pars interarticularis is challenging because of acting heavy forces on the lumbosacral joint. Facetectomies, nerve root decompression, and circumferential instrumented fusion are ways to decompress the neural elements, restore alignment, and maintain segmental stability.
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Multicenter Study
Prevalence and predictors of pain in surgical treatment of adolescent idiopathic scoliosis.
Multicenter, prospective, consecutive clinical series. ⋯ Back pain affects three-quarters of adolescents with idiopathic scoliosis and is reduced after posterior fusion. Patients who are overweight, older, and have larger proximal thoracic curve magnitudes report more preoperative pain. Patients who view themselves as more deformed tend to have more absolute pain, and less reduction in pain after operation.