Spine
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Retrospective study. ⋯ The VBQ score was an influential factor associated with lumbar pedicle screw loosening, and a higher VBQ score was significantly correlated with a higher risk of screw loosening. The VBQ score was a better predictor of pedicle screw loosening than the HU value in patients who underwent pedicle screw fixation for degenerative lumbar disease.
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Retrospective review of prospectively collected multisurgeon data. ⋯ Level 4.
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Experimental analysis of circular RNA in intervertebral disk degeneration (IDD). ⋯ Circ-CDR1as binds to miR-432-5p and plays a protective role in mitigating compression-induced NP cell apoptosis and ECM degradation by targeting SOX9. Circ-CDR1as may provide a novel therapeutic target for the clinical management of IDD in the future.
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Meta Analysis
Repurposing Antihypertensive and Statin Medications for Spinal Pain: A Mendelian Randomization Study.
Mendelian randomization (MR) study. ⋯ A protective effect of beta-blockers on spinal pain was suggested in the current study, consistent with findings from observational studies of various other pain phenotypes. The detrimental effect of calcium channel blockers on spinal pain suggested in the current study must be interpreted in the context of conflicting directions of effect on nonspinal pain phenotypes in other observational studies.This Mendelian randomization study examined whether antihypertensive medications (beta-blockers, calcium channel blockers, and angiotensin-converting enzyme inhibitors) and statins can be repurposed to prevent or treat spinal.This was a two-sample MR study using publicly available summary statistics from large-scale genome-wide association studies ranging size from 173,082 to 1,028,947 adults.While no statistically significant associations were found, a protective effect of beta-blockers on spinal pain was suggested (odds ratio [OR] 0.84, 95% confidence interval [CI] 0.72 to 0.98; p= 0.03), as was a detrimental effect of calcium channel blockers on spinal pain (OR 1.12, 95% CI 1.02 to 1.24; p= 0.02).
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Multicenter Study
Surgical Outcomes of Cerebral Palsy Patients with Scoliosis and Lumbar Hyperlordosis: A Comparative Analysis with 2-year Minimum Follow-up.
Retrospective review of a prospectively collected multicenter database. ⋯ 3.