Clinical nuclear medicine
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Clinical nuclear medicine · Sep 1995
Comparative StudyPrediction of pulmonary function after resection of primary lung cancer. Utility of inhalation-perfusion SPECT imaging.
To help determine whether preoperative perfusion and inhalation SPECT imagings are useful in predicting postoperative lung function, Tc-99m MAA perfusion SPECT imaging, CT scans, and pulmonary function tests were prospectively performed in 33 patients with primary lung cancer before and after lobectomy or pneumonectomy. Tc-99m Technegas inhalation SPECT imaging was performed in 6 of 33 patients as well. The authors also studied changes in radioactivity on the operated and nonoperated sides before and after surgery, examined the lowest limit value for adaptability to the operation, and made a comparison of both perfusion and inhalation SPECT imaging. ⋯ This appears to indicate that pulmonary blood flow on the operated side has completely recovered by 3 months after surgery. However, radioactivity in both the upper and lower lobes of the nonoperated side increased soon after surgery compared with that before the operation, and had not returned to preoperative levels 6 months after surgery. The radioactivity in the right middle lobe did not change before and after surgery.(ABSTRACT TRUNCATED AT 250 WORDS)
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Clinical nuclear medicine · Sep 1995
Comparative StudyDiminished Tc-99m HMPAO pulmonary uptake in ex-smokers.
Normally, there is no localization of Tc-99m HMPAO in the lungs. Tc-99m uptake in smokers' lungs has been reportedly higher than in nonsmokers. Thus, the lung uptake may be used as a barometer of cigarette smoking. ⋯ The authors conclude that pulmonary Tc-99m HMPAO uptake of smokers is significantly diminished after quitting smoking. However, the lung uptake of ex-smokers is higher than that of non-smokers. The uptake in the lung induced by smoking appears to be partially reversible after the cessation of smoking.