Clinical nuclear medicine
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Clinical nuclear medicine · Feb 2015
Effect of external magnetic field on IV 99mTc-labeled aminosilane-coated iron oxide nanoparticles: demonstration in a rat model: special report.
Among the most interesting applications of ferromagnetic nanoparticles (NPs) in medicine is the potential for localizing pharmacologically or radioactively tagged agents directly to selected tissues selected by an adjustable external magnetic field. This concept is demonstrated by the application external magnetic field on IV Tc-labeled aminosilane-coated iron oxide NPs in a rat model. In a model comparing a rat with a 0.3-T magnet over a hind paw versus a rat without a magnet, a static acquisition at 45 minutes showed that 27% of the administered radioactivity was in the area subtended by the magnet, whereas the liver displays a percentage of binding of 14% in the presence of the magnet and of 16% in the absence of an external magnetic field. These preliminary results suggest that the application of an external magnetic field may be a viable route for the development of methods for the confinement of magnetic NPs labeled with radioactive isotopes targeted for predetermined sites of the body.
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Clinical nuclear medicine · Jan 2015
Case ReportsPulmonary artery angiosarcoma on 18F-FDG PET/CT masquerading as pulmonary embolism.
A 53-year old woman suspicious for having pulmonary embolism on enhanced chest CT was proven to have metabolically active tumor in her pulmonary arteries on F-FDG PET/CT. Through biopsy and surgery, this turned out to be a pulmonary artery angiosarcoma. This case demonstrates that PET/CT is very useful in differentiating an aggressive malignant tumor from a bland pulmonary embolus in the pulmonary vasculature.
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Clinical nuclear medicine · Jan 2015
Standing prone positioning in establishing causality between matched ventilation-perfusion defects and pleural effusion.
Ventilation-perfusion scintigraphy is routinely performed in patients with suspected pulmonary thromboembolism. Pleural effusions in such patients are common and can cause matched ventilation-perfusion defects. ⋯ Prone positioning has been described as a useful technique to redistribute pleural fluid anteriorly, exposing perfusion in posterior lung fields; however, some patients have a concurrent condition that renders prone positioning difficult. This report discusses a modified technique that allows patients to be imaged in a standing prone position with excellent results.
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Clinical nuclear medicine · Nov 2014
Case ReportsHypermetabolism during resting-state FDG-PET suggesting intrinsic epileptogenicity in focal cortical dysplasia.
We report the case of a 21-year-old man who presented drug-resistant epilepsy since the age of 3 years. The underlying type Ia left prefrontal focal cortical dysplasia was revealed by focal hypermetabolism of FDG-PET several years later. ⋯ The surgical limits of resection were defined based on interictal activity, spontaneous and induced seizures. The patient is seizure-free, with normal electroencephalography and clear improvement of neuropsychological performance, without functional deficit at 3 years postsurgery.
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Clinical nuclear medicine · Oct 2014
Case ReportsSerial FDG PET/CT in autoimmune encephalitis with faciobrachial dystonic seizures.
Autoimmune encephalitis (AE) is increasingly recognized as a nonparaneoplastic disorder with autoantibodies to neuronal proteins. Although MRI is frequently unremarkable, PET imaging might contribute to identification of affected brain regions in distinct AE. We report on serial FDG PET in a 72-year-old man with particular AE subtype, with potassium channel complex antibodies and prodromal stage with dystonic seizures. Serial FDG PET/CT revealed that besides limbic structures, basal ganglia are centrally involved and presumably play a key role in the generation of dystonic seizures.