Psychoneuroendocrinology
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Psychoneuroendocrinology · Jun 2004
Randomized Controlled Trial Comparative Study Clinical TrialSalivary cortisol sampling compliance: comparison of patients and healthy volunteers.
Problems of compliance with in vivo data collection and treatment protocols have been identified. This study investigated compliance with salivary cortisol sampling in a 7-day protocol. Impact of non-compliance on cortisol data was evaluated. ⋯ Self-report of compliance in a salivary cortisol sampling protocol substantially overestimates actual compliance in the absence of objective monitoring. Non-compliance with the sampling protocol results in cortisol data that significantly differs from compliant data. Awareness of electronic monitoring of sampling results in satisfactory compliance.