Psychoneuroendocrinology
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Psychoneuroendocrinology · Jan 2007
Randomized Controlled TrialCharacterization of verbal and spatial memory changes from moderate to supraphysiological increases in serum testosterone in healthy older men.
It has been suggested that cognitive changes in response to T supplementation may occur within an ideal range. The objective of this study was to compare the cognitive responses of older, eugonadal men in whom moderate or large increases in serum testosterone levels was induced by exogenous testosterone supplementation. ⋯ These results suggest that in healthy older men, beneficial changes in cognitive function induced by T supplementation are most evident with moderate changes in cognition from moderate to high T supplementation increases in T levels. Large or no to low increases in T levels do not appear to appreciably effect cognition.