Investigative ophthalmology & visual science
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Invest. Ophthalmol. Vis. Sci. · Oct 1996
Adenosine mediates hypoxic induction of vascular endothelial growth factor in retinal pericytes and endothelial cells.
To determine the mechanistic role for adenosine and adenosine receptors in the hypoxic induction of vascular endothelial growth factor (VEGF) in retinal microvascular cells. ⋯ These data suggest that the hypoxia-induced accumulation of adenosine stimulates VEGF gene expression through stimulation of adenosine A2a receptor and subsequent activation of the cAMP-dependent protein kinase A pathway in retinal vascular cells.