Investigative ophthalmology & visual science
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Invest. Ophthalmol. Vis. Sci. · Sep 1996
The involvement of polyamines in the proliferation of cultured retinal pigment epithelial cells.
To investigate the involvement of polyamines (putrescine, spermidine, and spermine) in the proliferation of retinal pigment epithelium (RPE) using cultured bovine RPE cells. ⋯ Polyamines are essential for the proliferation of cultured bovine RPE cells. These data suggest that, of the polyamines, spermine has the greatest effect on DNA synthesis although other polyamines can substitute for spermine at higher concentrations with similar results. As for polyamine metabolism in RPE proliferation, it is possible that SAMDC is the key enzyme rather than ODC.