Investigative ophthalmology & visual science
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Invest. Ophthalmol. Vis. Sci. · Aug 1997
Proteoglycans in the human sclera. Evidence for the presence of aggrecan.
The proteoglycans synthesized and accumulated within the adult human sclera (aged 50 to 80 years) were identified by their size, glycosaminoglycan side chains, and core proteins in an effort to characterize the proteoglycan content of the human sclera. ⋯ The adult human sclera contains three major proteoglycans; aggrecan, biglycan, and decorin. It is likely that these proteoglycans contribute to the structural properties of the sclera and that the ratios of these proteoglycans will change with age, specific region, and condition of the sclera.