Investigative ophthalmology & visual science
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To determine whether the Goldmann applanation tonometer can be modified to measure intraocular pressure (IOP) in the awake mouse. ⋯ The Goldmann tonometer, the standard for measuring the IOP in the human eye, was modified to measure this fundamental physiologic parameter in the awake mouse. This measurement is required to confirm success in genetically engineering a model in the powerful mouse system, which mimics elevated IOP in humans. The model will open new avenues for studying the causes of the optic neuropathy of glaucoma, the regulation of IOP, and new therapeutic approaches to prevent the irreversible loss of vision from this disease.