Investigative ophthalmology & visual science
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Invest. Ophthalmol. Vis. Sci. · Nov 2006
The Impact of Vision Impairment Questionnaire: an evaluation of its measurement properties using Rasch analysis.
To explore the psychometric properties of the Impact of Vision Impairment scale (IVI) by using Rasch analysis. ⋯ The results provide support for the measurement properties of the Rasch-scaled 28-item version of the IVI and of its potential for assessing outcomes of low-vision rehabilitation. A raw score-to-Rasch person measure conversion is supplied.
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Invest. Ophthalmol. Vis. Sci. · Nov 2006
Comparative Study Clinical TrialShort-term effects of latanoprost on anterior chamber depth in patients with glaucoma or ocular hypertension.
Prostaglandin F(2alpha) analogues, such as latanoprost, may cause a decrease in the extracellular matrices, such as collagen, and changes in fibrillin-1; both are components of the ciliary zonules. However, the mechanical effect of these changes on the dynamics of the ciliary zonules is unknown. This study was conducted to evaluate the effect of latanoprost 0.005% on anterior chamber depth (ACD), best corrected visual acuity (BCVA), lens thickness, and anterior chamber dynamics in patients with glaucoma or ocular hypertension. ⋯ These findings suggest that latanoprost decreases ACD in patients with glaucoma or ocular hypertension after 1 month of treatment.
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Invest. Ophthalmol. Vis. Sci. · Nov 2006
Safety testing of indocyanine green in an ex vivo porcine retina model.
To assess retinal toxicity of indocyanine green (ICG) in a porcine ex vivo perfusion organ culture model, and to measure intraretinal penetration of ICG applied to the retinal surface. ⋯ ICG induced apoptosis but not necrosis in all nuclear retinal layers in a dose-dependent manner. Brief exposure to ICG 0.1% for 1 minute and illumination for 3 minutes simulated the intraoperative use of ICG. No retinal apoptosis or necrosis was observed. ICG briefly applied to the retinal surface gradually penetrated the entire retina.