Investigative ophthalmology & visual science
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Invest. Ophthalmol. Vis. Sci. · Apr 2006
Blockade of the interaction of leukotriene b4 with its receptor prevents development of autoimmune uveitis.
To investigate the role of leukotriene B4 (LTB4) and its receptor BLT1 in the pathogenesis of mouse uveitis. ⋯ The results demonstrate a critical role for LTB4 in ocular inflammation and in the development and progression of EAU and suggest a new potential target for therapeutic intervention in this disease.