Investigative ophthalmology & visual science
-
Invest. Ophthalmol. Vis. Sci. · Dec 2009
Role of formation of an ERK-FAK-paxillin complex in migration of human corneal epithelial cells during wound closure in vitro.
Migration of corneal epithelial cells is an important step in the corneal wound healing. The role of extracellular signal regulated kinase (ERK) for the regulation of cell migration during wound closure was examined. ⋯ ERK regulates cell migration during wound healing in vitro by modulating the phosphorylation of FAK and paxillin and the consequent formation of focal adhesions. An ERK-FAK-paxillin signaling pathway may play an important role in corneal epithelial wound healing in vivo.