Investigative ophthalmology & visual science
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Invest. Ophthalmol. Vis. Sci. · Sep 2009
Retrobulbar optic nerve diameter measured by high-speed magnetic resonance imaging as a biomarker for axonal loss in glaucomatous optic atrophy.
To assess a novel magnetic resonance imaging (MRI) protocol for quantifying the optic nerve diameter (OND) as a measure of axonal loss in the optic nerve. ⋯ Retina- or optic nerve head-related surrogate markers for axonal content correlated closely with the OND, although only when it was measured in the orbital apex. High-resolution MRI using an ultrafast HASTE-sequence at 3 T proved useful for OND quantification and may be a valuable asset in future neuroprotection trials.
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Invest. Ophthalmol. Vis. Sci. · Sep 2009
Activated CD11b+ CD15+ granulocytes increase in the blood of patients with uveal melanoma.
To determine whether activated CD11b(+) CD15(+) granulocytes increase in the blood of patients with uveal melanoma. ⋯ Activated CD11b(+) CD15(+) granulocytes expand in the blood of patients with uveal melanoma and may contribute to immune evasion by ocular tumors by inhibiting T-cell function via decreasing CD3zeta chain expression.