Investigative ophthalmology & visual science
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Invest. Ophthalmol. Vis. Sci. · Apr 2011
Randomized Controlled Trial Multicenter StudyProgressive-addition lenses versus single-vision lenses for slowing progression of myopia in children with high accommodative lag and near esophoria.
To determine whether progressive-addition lenses (PALs) relative to single-vision lenses (SVLs) slow the progression of low myopia in children with high accommodative lag and near esophoria. ⋯ The PALs used in this study were found to have a statistically but not clinically significant effect of slowing myopia progression in children with high accommodative lag and near esophoria. (ClinicalTrials.gov number, NCT00320593.).
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Invest. Ophthalmol. Vis. Sci. · Apr 2011
Metabolic syndrome components and age-related cataract: the Singapore Malay eye study.
To examine the relationship between metabolic syndrome and its components, diabetes mellitus, high blood pressure (BP), obesity, and dyslipidemia, with age-related cataract. ⋯ Metabolic syndrome and its two key components, high BP and diabetes were associated with age-related cataract.
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Invest. Ophthalmol. Vis. Sci. · Apr 2011
Agonists at the serotonin receptor (5-HT(1A)) protect the retina from severe photo-oxidative stress.
5-HT(1A) agonists are neuroprotective in CNS injury models. The authors evaluated the efficacy of 5-HT(1A) agonists to protect the retina from severe blue light-induced photo-oxidative damage. ⋯ 5-HT(1A) agonists provided potent and complete functional and structural protection. Protection was inhibited by treatment with WAY-100635, confirming the requirement for activating the 5-HT(1A) receptor in initiating this survival pathway. Single-dose experiments with AL-8309A suggest that the mechanism of protection is rapidly activated and protection persists for 48 hours. AL-8309B (1.75%) was effective after topical ocular dosing. AL-8309B is under evaluation in the clinic and may be useful in treating age-related macular degeneration.
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Invest. Ophthalmol. Vis. Sci. · Apr 2011
Potentiating action of propofol at GABAA receptors of retinal bipolar cells.
Propofol (2,6-diisopropyl phenol), a widely used systemic anesthetic, is known to potentiate GABA(A) receptor activity in a number of CNS neurons and to produce changes in electroretinographically recorded responses of the retina. However, little is known about propofol's effects on specific retinal neurons. The authors investigated the action of propofol on GABA-elicited membrane current responses of retinal bipolar cells, which have both GABA(A) and GABA(C) receptors. ⋯ Propofol exerts a marked and selective potentiation on GABA(A) receptors of retinal bipolar cells. The data encourage the use of propofol in future studies of bipolar cell function.