Investigative ophthalmology & visual science
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Invest. Ophthalmol. Vis. Sci. · Jun 2011
Comparative StudyA lipid nanoparticle system improves siRNA efficacy in RPE cells and a laser-induced murine CNV model.
To explore the possibility of the PEGylated liposome-protamine-hyaluronic acid nanoparticles (PEG-LPH-NP) loaded with siRNA (PEG-LPH-NP-S) in ARPE19 cells and a laser-induced rat model for the treatment of choroidal neovascularization (CNV). ⋯ PEG-LPH-NP may be a promising lipid nanoparticle system for the siRNA treatment of CNV.