Investigative ophthalmology & visual science
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Invest. Ophthalmol. Vis. Sci. · Feb 2012
Comparative StudyEphA2/Ephrin-A1 signaling complexes restrict corneal epithelial cell migration.
Eph/ephrin signaling proteins are present in the corneal epithelium, where their function remains unknown. The authors examined the role of the EphA2 receptor and ephrin-A1 ligand in human corneal epithelial cell migration. ⋯ EphA2 attenuates corneal epithelial cell migration when stimulated by ephrin-A1 ligand in a manner that involves the suppression of Akt. Elevated levels of ephrin-A1 may contribute to diabetic keratopathies by persistently engaging EphA2 and prohibiting Akt-dependent corneal epithelial repair processes.
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Neuroglobin (Ngb) is a vertebrate globin that is predominantly expressed in the retina and brain. To explore the role of Ngb in retinal neuroprotection during ischemia reperfusion (IR), the authors examined the effect of Ngb overexpression in the retina in vivo by using Ngb-transgenic (Ngb-Tg) mice. ⋯ Neuroglobin overexpression plays a neuroprotective role against retinal ischemia reperfusion injury due to decreasing of mitochondrial oxidative stress-mediated apoptosis.
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Invest. Ophthalmol. Vis. Sci. · Nov 2011
Barriers to low vision rehabilitation: the Montreal Barriers Study.
One objective of the Montreal Barriers Study was to examine demographic characteristics of people with vision impairment that may hinder their referral or decision to access rehabilitation services. ⋯ It seems that even under ideal referral situations, there remain barriers to vision rehabilitation services that have not been specifically identified in the present study. Further research is necessary on the psychological and psychosocial contributors to this process.
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Invest. Ophthalmol. Vis. Sci. · Oct 2011
Visual prognostic value of optical coherence tomography and photopic negative response in chiasmal compression.
To investigate the potential of the optical coherence tomography (OCT) measurement of retinal nerve fiber layer (RNFL) thickness and ganglion cell complex (GCC) area and photopic negative response (PhNR) for predicting postoperative visual outcome in chiasmal compression, prospectively. ⋯ An eye with the more demonstrable structural deterioration, as shown by reduced RNFL thickness and GCC area, and retinal ganglion cell dysfunction as shown by decreased PhNR/b-wave amplitude ratio was associated with the worse visual fields outcome. RNFL thickness and GCC area measurements using OCT and PhNR/b-wave amplitude ratio could be a useful prognostic indicator in the preoperative assessment of chiasmal compression.