Investigative ophthalmology & visual science
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Invest. Ophthalmol. Vis. Sci. · Jan 2016
Multicenter StudyCase-Control Pilot Study of Soft Contact Lens Wearers With Corneal Infiltrative Events and Healthy Controls.
The purpose of this study was to assess risk factors associated with soft contact lens (SCL)-related corneal infiltrative events (CIEs). ⋯ This pilot study demonstrated feasibility of enrolling a representative pool of SCL wearers with an untreated, symptomatic CIE and assessing CIE risk factors by using standardized methods. A larger sample size is needed to determine relationships between patient-reported behaviors and exposures, microbial bioburden, and CIE development.
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Invest. Ophthalmol. Vis. Sci. · Nov 2014
Multicenter Study Clinical TrialBaseline OCT measurements in the idiopathic intracranial hypertension treatment trial, part I: quality control, comparisons, and variability.
Optical coherence tomography (OCT) has been used to investigate papilledema in single-site, mostly retrospective studies. We investigated whether spectral-domain OCT (SD-OCT), which provides thickness and volume measurements of the optic nerve head and retina, could reliably demonstrate structural changes due to papilledema in a prospective multisite clinical trial setting. ⋯ Spectral-domain OCT provides reliable continuous variables and quantified assessment of structural alterations due to papilledema. (ClinicalTrials.gov number, NCT01003639.).
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Invest. Ophthalmol. Vis. Sci. · Apr 2011
Randomized Controlled Trial Multicenter StudyProgressive-addition lenses versus single-vision lenses for slowing progression of myopia in children with high accommodative lag and near esophoria.
To determine whether progressive-addition lenses (PALs) relative to single-vision lenses (SVLs) slow the progression of low myopia in children with high accommodative lag and near esophoria. ⋯ The PALs used in this study were found to have a statistically but not clinically significant effect of slowing myopia progression in children with high accommodative lag and near esophoria. (ClinicalTrials.gov number, NCT00320593.).
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Invest. Ophthalmol. Vis. Sci. · Nov 2008
Randomized Controlled Trial Multicenter Study Comparative StudyA randomized trial of the effect of soft contact lenses on myopia progression in children.
Soft contact lenses have been reported to increase the progression of myopia. The purpose of this study was to determine whether soft contact lenses affect the progression of myopia in children. ⋯ These data provide reassurance to eye care practitioners concerned with the phenomenon of "myopic creep." Soft contact lens wear by children does not cause a clinically relevant increase in axial length, corneal curvature, or myopia relative to spectacle lens wear. (ClinicalTrials.gov, NCT00522288.).
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Invest. Ophthalmol. Vis. Sci. · Aug 2005
Multicenter Study Comparative Study Clinical TrialPreschool vision screening tests administered by nurse screeners compared with lay screeners in the vision in preschoolers study.
To compare the performance of nurse screeners with that of lay screeners in administering preschool vision screening tests. ⋯ Nurse and lay screeners can achieve similar sensitivity, when specificity is set at 0.90, for detecting preschool children in need of a comprehensive eye examination.