Investigative ophthalmology & visual science
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Invest. Ophthalmol. Vis. Sci. · Aug 2010
Cold-sensitive corneal afferents respond to a variety of ocular stimuli central to tear production: implications for dry eye disease.
To investigate the response characteristics of the corneal afferents that detect ocular conditions critical to the activation of the "afferent limb" of the lacrimation reflex. ⋯ These results demonstrate that innocuous "cold" cornea thermoreceptors are activated by drying of the ocular surface and hyperosmotic solutions, conditions that are consistent with a role in tear production. The authors hypothesize that the dysfunction of these corneal afferents and the lacrimation reflex pathway they activate lead to some forms of dry eye disease.
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Invest. Ophthalmol. Vis. Sci. · Jul 2010
Rotterdam AMblyopia screening effectiveness study: detection and causes of amblyopia in a large birth cohort.
PURPOSE. The Dutch population-based child health monitoring program includes regular preverbal (age range, 1-24 months) and preschool (age range, 36-72 months) vision screening. This study is on the contribution of an organized vision screening program to the detection of amblyopia. ⋯ CONCLUSIONS. Most cases of amblyopia were detected by vision screening with visual acuity measurement. Preverbal screening contributed little to the detection of refractive amblyopia.
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Invest. Ophthalmol. Vis. Sci. · Apr 2010
Primary care provider views of the current referral-to-eye-care process: focus group results.
Purpose. To understand the barriers facing primary care providers (PCPs), including nurse practitioners (NPs) and physician assistants (PAs), in the current referral-to-eye-care process and to solicit suggestions from PCPs on how to improve the current referral system. Methods. ⋯ PCPs desire change(s) in the current referral-to-eye-care system. Better communication between PCPs and ECPs, further implementation of EMRs, and increasing eye screening in primary care clinics were common themes. Implementing specific suggestions, such as modernizing medical record systems, may help to increase eye care utilization among patients at high risk for advancing eye disease and vision loss.
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Invest. Ophthalmol. Vis. Sci. · Mar 2010
The dependence of retinal degeneration caused by the rhodopsin P23H mutation on light exposure and vitamin a deprivation.
To characterize the influence of light and vitamin A on retinal degeneration in an animal model of retinitis pigmentosa caused by the rhodopsin P23H mutation. ⋯ The mechanism of retinal degeneration in this animal model of RP involves the interaction of light with rhodopsin rather than with free chromophore or bleached rhodopsin. These results may explain the clinical benefits of vitamin A for patients with retinitis pigmentosa and may indicate that pharmacological chaperones are a viable approach to RP therapy. Results also suggest strategies for minimizing RD in patients through controlling light exposure duration or wavelengths.
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Invest. Ophthalmol. Vis. Sci. · Feb 2010
Clinical TrialNormative measurements of the Chinese extraocular musculature by high-field magnetic resonance imaging.
To establish the normal measurements of diameter and cross-sectional area of the Chinese extraocular muscles (EOMs) and optic nerve-sheath complex (ON) as seen on high-field (3-Tesla; 3T) magnetic resonance imaging (MRI). ⋯ The Chinese 3T MRI EOMs and ON normative data may be useful in determining pathologic enlargement of the EOMs and ON in various orbital conditions. (ClinicalTrials.gov number, NCT00348413.).