Intensive care medicine
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Intensive care medicine · May 1996
Comparative StudyBlood lactate levels are better prognostic indicators than TNF and IL-6 levels in patients with septic shock.
Both serum levels of tumor necrosis factor-alpha (TNF alpha) and interleukin-6 (IL-6) and blood lactate levels in patients with septic shock have been shown to correlate with prognosis. The aim of the study was to define the relative predictive value of these measures. ⋯ These data indicate that the large variability in TNF alpha and IL-6 levels limit their prognostic significance in patients with septic shock. The predictive value of the trend in cytokine levels over time is not superior to that of trends in blood lactate levels.
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Intensive care medicine · May 1996
Inhalation of prostacyclin (PGI2) for 8 hours does not produce signs of acute pulmonary toxicity in healthy lambs.
To study the potential side effects and toxicity of inhaling prostacyclin (PGI2) aerosol for 8 h. ⋯ Inhalation of PGI2 (28 ng/kg per min) over a period of 8 h in healthy lambs does not produce major side effects or acute pulmonary toxicity.
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Intensive care medicine · May 1996
Review Comparative Study Clinical Trial Controlled Clinical TrialContinuous measurement of cardiac output by the Fick principle in infants and children: comparison with the thermodilution method.
To compare a system that continuously monitors cardiac output by the Fick principle with measurements by the thermodilution technique in pediatric patients. ⋯ Continuous measurement of cardiac output by the Fick principle offers a convenient method for the hemodynamic monitoring of unstable infants and children.
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Intensive care medicine · May 1996
Multicenter Study Comparative Study Clinical TrialClinical evaluation of a multiparameter intra-arterial blood-gas sensor.
To evaluate the in vivo performance of a continuous, intra-arterial, multiparameter blood-gas sensor containing a thermocouple, miniaturized polarographic oxygen electrode, as well as fiberoptic pH and pCO2 sensors. ⋯ Clinical performance of this intra-arterial, multiparameter blood-gas sensor demonstrated stability, consistency, and accuracy comparable to laboratory blood-gas analyzers. The present multiparameter, intravascular blood-gas sensor, when inserted in the radial artery, can provide stable and accurate monitoring of pH, PaCO2, and PaO2 over clinically relevant periods of as long as 6 days in the critical care setting.